Editorial: therapeutic drug monitoring for anti-TNF agents-has it all been said?

Is the Therapeutic Drug Monitoring of Anti-TNF Agents Necessary in Korean Inflammatory Bowel Disease Patients?

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are idiopathic chronic intestinal inflam-matory diseases, characterized by recurrent episodes of relapse and remission of disease. The introduction of anti-tumor necro-sis factor (anti-TNF) agents has greatly improved the treatment outcomes for IBDs, enabling higher rates of clinical and endo-scopic remission i...

[Therapeutic drug monitoring of antifungal agents].

Monitoring Anti-Tnf Drug Treatment in Inflammatory Bowel Disease. Is it Useful in Clinical Practice?

Submit Manuscript | http://medcraveonline.com Despite their efficacy, approximately 30% of patients do not respond to these therapies, and up to 40% of those who do respond lose efficacy over time [6]. To date, when faced with the failure to respond, the approach was to act empirically by intensifying the employed anti-TNF or by changing to another anti-TNF or a drug with a different therapeuti...

Therapeutic Drug Monitoring of TNF Antagonists in Inflammatory Bowel Disease.

Although tumor necrosis factor (TNF)-α antagonists play a critical role in the treatment of moderate-to-severe inflammatory bowel disease (IBD), several factors can impact treatment response. The degree of systemic inflammation, serum albumin concentration, disease type, body mass index, gender, concomitant therapy with immunosuppressive agents, and especially development of antidrug antibodies...

Has It Always Been the Best Thiazide-type Diuretic? Editorial Commentary

Modern diuretic therapy evolved from 2 seemingly unrelated events in the 1930s: the development of sulfanilamide, the first truly effective antibacterial agent, and the description of the enzyme carbonic anhydrase. Sulfanilamide was observed to increase sodium (Na )/potassium and water excretion by inhibition of carbonic anhydrase activity. Recognition of this action proved the impetus for synt...